Cholesterol and Presynaptic Glutamate Transport in the Brain

Cholesterol and Presynaptic Glutamate Transport in the Brain

Glutamate is the primary excitatory neurotransmitter in the CNS and disturbances in glutamate transport contribute to a number of neurological and neurodegenerative disorders.  Appropriate levels of cholesterol are very important for the proper functioning of glutamate transport while unbalanced lev...

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Bibliographic Details
Main Author: Borisova, Tatiana (Author)
Corporate Author: SpringerLink (Online service)
Format: Electronic eBook
Language:English
Published: New York, NY : Springer New York : Imprint: Springer, 2013.
Series:SpringerBriefs in Neuroscience, 12
Subjects:
Medicine.
Neurosciences.
Neurochemistry.
Biomedicine.
Online Access:Full Text via HEAL-Link
Table of Contents:
  • Presynaptic glutamate transport in the brain
  • Cholesterol and its role in synaptic transmission
  • Effects of cholesterol-depleting agent methyl-b-cyclodextrin (MbCD) on the functional state of brain nerve terminals
  • The extracellular level and uptake of glutamate in cholesterol-deficient nerve terminals
  • Unstimulated and exocytotic glutamate release from cholesterol-deficient nerve terminals
  • Neuroprotection by lowering cholesterol.

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