Transporters in Drug Development Discovery, Optimization, Clinical Study and Regulation /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Sugiyama, Yuichi (Επιμελητής έκδοσης), Steffansen, Bente (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2013.
• Σειρά: AAPS Advances in the Pharmaceutical Sciences Series, 7
• Θέματα: Medicine.; Pharmaceutical technology.; Biomedicine.; Pharmaceutical Sciences/Technology.; Biomedicine general.

Transporters in Drug Development examines how membrane transporters can be dealt with in academic-industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the inte...

Πίνακας περιεχομένων:

• Membrane Transporters in ADME
• In Vitro Characterization of Transporter Mediated Permeability
• In Vitro Characterization of Interactions with Drug Transporting Proteins
• In Vivo Characterization of Interactions on Transporters
• Application of Targeted Proteomics in ADME for IVIVE
• Prediction of Transporter Mediated Drug-Drug Interaction from In Vitro Data
• Accounting for Transporters in Renal Clearance: Towards a Mechanistic Kidney Model (Mech KiM)
• Analysis of Intestinal Transporters
• Analysis of Hepatic Transport Proteins
• Analysis of Renal Transporters
• The Role of Transporters During Drug Development: Regulatory Science Perspective from the FDA
• Industrial Evaluation of Drug Transporters in ADME.