Pharmaco-Imaging in Drug and Biologics Development Fundamentals and Applications /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Moyer, Brian R. (Editor), Cheruvu, Narayan P.S (Editor), Hu, Tom C.-C (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2014.
• Series: AAPS Advances in the Pharmaceutical Sciences Series, 8
• Subjects: Medicine.; Pharmaceutical technology.; Biomedicine.; Biomedicine general.; Pharmaceutical Sciences/Technology.

Advances in drugs and biologics to mitigate or cure some of nature’s most complex medical problems have been incredible to behold.  These accomplishments are due to the actions of a wide theatre of participants from biologists, pharmacologists, geneticists, chemists and manufacturers, molecular biol...

Table of Contents:

• Imaging Platforms and Drug Development:  An Introduction
• Imaging in Drug Development: Animal Models, Handling and Physiological Constraints
• Considerations for Pre-Clinical Laboratory Animal Imaging Center Design, Setup, and Management suitable for Biomedical Investigation for Drug Discovery
• Pharmaco-Imaging in Translational Science and Research
• The Role of Pharmacokinetics and Allometrics in Imaging: Practical Issues and Considerations
• Quantitative Imaging Using Autoradiographic Techniques
• Pre-Clinical Imaging in Oncology: Considerations and Recommendations for the Imaging Scientist
• Use of Radiolabelled Leukocytes for Drug Evaluation in Man
• Application of Bioluminescence Imaging (BLI) to the Study of the Animal Models of Human Infectious Diseases
• Pre-Clinical Imaging in BSL-3 and BSL-4 Environments:  Imaging Pathophysiology of Highly Pathogenic Infectious Diseases
• Magnetic Resonance as a Tool for Pharmaco-Imaging
• Technologies and Principles of Mass Spectral Imaging
• Regulatory Considerations Involved In Imaging.