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131008s2013 xxu| s |||| 0|eng d |
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|a 9781461482895
|9 978-1-4614-8289-5
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|a 10.1007/978-1-4614-8289-5
|2 doi
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|a 611.01816
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|a Gadd45 Stress Sensor Genes
|h [electronic resource] /
|c edited by Dan A. Liebermann, Barbara Hoffman.
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|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 2013.
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|a X, 134 p. 18 illus., 11 illus. in color.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
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|a online resource
|b cr
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|a text file
|b PDF
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 793
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|a Gadd45 in stress signaling, cell cycle control and apoptosis -- Gadd45 in Modulation of Solid Tumors and Leukemia -- Gadd45 Proteins: Key players of repair-mediated DNA demethylation -- Gadd45 proteins in Immunity -- Gadd45 in the liver — Signal transduction and transcriptional mechanisms -- The Role of the Gadd45 Family in the Nervous System: A focus on Neurodevelopment, Neuronal Injury, and Cognitive Neuroepigenetics -- Gadd45 stress sensors in preeclampsia -- Index.
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|a Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins). These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity. Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress. Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus. Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved. .
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| 650 |
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|a Medicine.
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| 650 |
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|a Human genetics.
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| 650 |
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|a Medical genetics.
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|a Biochemistry.
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|a Biomedicine.
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|a Gene Function.
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|a Biochemistry, general.
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| 650 |
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|a Human Genetics.
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| 700 |
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|a Liebermann, Dan A.
|e editor.
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| 700 |
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|a Hoffman, Barbara.
|e editor.
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| 710 |
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|a SpringerLink (Online service)
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|t Springer eBooks
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| 776 |
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|i Printed edition:
|z 9781461482888
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| 830 |
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 793
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| 856 |
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|u http://dx.doi.org/10.1007/978-1-4614-8289-5
|z Full Text via HEAL-Link
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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