Targeted Cancer Treatment in Silico Small Molecule Inhibitors and Oncolytic Viruses /

• Κύριοι συγγραφείς: Komarova, Natalia L. (Συγγραφέας), Wodarz, Dominik (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Birkhäuser, 2014.
• Σειρά: Modeling and Simulation in Science, Engineering and Technology,
• Θέματα: Mathematics.; Cancer research.; Oncology.; Applied mathematics.; Engineering mathematics.; Biomathematics.; Physiological, Cellular and Medical Topics.; Cancer Research.; Mathematical and Computational Biology.; Genetics and Population Dynamics.; Applications of Mathematics.

This monograph provides the first in-depth study of how mathematical and computational approaches can be used to advance our understanding of cancer therapies and to improve treatment design and outcome. Over the past century, the search for a cancer cure has been a primary occupation of medical res...

Πίνακας περιεχομένων:

• Background and Scope of the Book
• Part I Treatment of Cancer with Small Molecule Inhibitors
• An Introduction to Small Molecule Inhibitors and Chronic Myeloid Leukemia
• Basic Dynamics of Chronic Myeloid Leukemia During Imatinib Treatment
• Stochastic Modeling of Cellular Growth, Treatment, and Resistance Generation
• Evolutionary Dynamics of Drug Resistant Mutants in Targeted Treatment of CML
• Effect of Cellular Quiescence on the Evolution of Drug Resistance in CML
• Combination Therapies: Short term versus Long term Strategies
• Cross Resistance: Treatment and Modeling
• Mathematical Modeling of Cyclic Cancer Treatments
• Part II Treatment of Cancer with Oncolytic Viruses
• Introduction to Oncolytic Viruses
• Basic Dynamics of Oncolytic Viruses
• Mitotic Virus Transmission and Immune Responses
• Axiomatic Approaches to Oncolytic Virus Modeling
• Spatial Oncolytic Virus Dynamics
• Oncolytic Viruses and the Eradication of Drug-resistant Tumor Cells.