Molecular Pathogenesis of Colorectal Cancer

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Haigis, Ph.D., Kevin M. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2013.
• Θέματα: Medicine.; Cancer research.; Molecular biology.; Proteins.; Cell biology.; Biomedicine.; Cancer Research.; Molecular Medicine.; Protein Science.; Cell Biology.

For more than two decades, colorectal cancer has served as the paradigm for the cooperative activity of oncogenes and tumor suppressor genes in cancer initiation and progression. The depth of molecular characterization for this disease is unparalleled, with specific mutations correlated to each hist...

Πίνακας περιεχομένων:

• Preface
• The Genetics of Colorectal Cancer
• Molecular Mechanisms of Colorectal Carcinogenesis
• The association between inflammation and colorectal cancer
• Importance of the niche: Wnt signalling and Stem cell plasticity in intestinal homeostasis and disease
• Mutational activation of KRAS and BRAF in colorectal cancer
• The PI3K pathway in Colorectal Cancers
• TGF-ß signaling pathway and colorectal cancer
• The Clinical Significance of Mutations in Colorectal Cancer
• Colorectal Cancer Genome and Its Implications
• Copy-Number Alterations in the Colorectal Cancer Genome
• Genome-wide association studies in colorectal cancer
• Future prospects for leveraging molecular information in the fight against colorectal cancer
• Index.