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02786nam a22004935i 4500 |
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978-1-4614-8778-4 |
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DE-He213 |
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20151204144309.0 |
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cr nn 008mamaa |
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131128s2014 xxu| s |||| 0|eng d |
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|a 9781461487784
|9 978-1-4614-8778-4
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|a 10.1007/978-1-4614-8778-4
|2 doi
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|a QH301-705
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|a 570
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|a Systems Analysis of Human Multigene Disorders
|h [electronic resource] /
|c edited by Natalia Maltsev, Andrey Rzhetsky, T. Conrad Gilliam.
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|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 2014.
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|a XIII, 122 p. 12 illus. in color.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
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|a text file
|b PDF
|2 rda
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 799
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| 505 |
0 |
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|a Wellness and Health Omics Linked to the Environment: the WHOLE approach to personalized medicine -- Characterizing Multi-omic Data in Systems Biology -- High-throughput Translational Medicine: Challenges and Solutions -- Computational approaches for human disease gene prediction and ranking -- A Personalized Treatment for Lung Cancer: Molecular Pathways, Targeted Therapies, and Genomic Characterization -- Index.
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| 520 |
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|a Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance.
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| 650 |
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|a Life sciences.
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| 650 |
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|a Human genetics.
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| 650 |
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|a Systems biology.
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| 650 |
1 |
4 |
|a Life Sciences.
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| 650 |
2 |
4 |
|a Systems Biology.
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| 650 |
2 |
4 |
|a Human Genetics.
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| 700 |
1 |
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|a Maltsev, Natalia.
|e editor.
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| 700 |
1 |
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|a Rzhetsky, Andrey.
|e editor.
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| 700 |
1 |
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|a Gilliam, T. Conrad.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 776 |
0 |
8 |
|i Printed edition:
|z 9781461487777
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| 830 |
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 799
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1007/978-1-4614-8778-4
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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