Molecular Determinants of Head and Neck Cancer

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Burtness, Barbara (Επιμελητής έκδοσης), Golemis, Erica A. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2014.
• Σειρά: Current Cancer Research
• Θέματα: Medicine.; Cancer research.; Oncology.; Proteins.; Biomedicine.; Cancer Research.; Protein Science.

Head and neck cancers, involving sites from the nasopharynx to the subglottic larynx, are frequently devastating cancers that afflict patients around the world. These cancers are frequently locally advanced prior to detection, and require multimodality therapy that is associated with high morbidity....

Πίνακας περιεχομένων:

• Overview: The Pathobiology of Head and Neck Cancer
• Human papillomavirus (HPV)-positive head and neck cancer and the Wnt signaling pathway
• EGFR Inhibitors as Therapeutic Agents in Head and Neck Cancer
• The Role of HGF/c-MET in Head and Neck Squamous Cell Carcinoma
• Insulin-like Growth Factor-1 Receptors in Head and Neck Cancer
• The PI3K Signaling Pathway in Head and Neck Squamous Cell Carcinoma
• Jak/STAT Signaling in HNC
• TGFβ regulates EMT in head and neck cancer
• p53 in Head and Neck Cancer
• DNA damage proteins and response to therapy in head and neck cancer
• Hypoxia and radioresistance in head and neck cancer
• The Wnt β-catenin Signaling Circuitry in Head and Neck Cancer
• Sequencing HNC: Emergence of Notch Signaling
• Gene Expression in HNC
• Epidemiology of HPV in Head and Neck Cancer; variant strains, discrete protein function
• Projections: Novel Therapies for HPV-Negative Cancers of the Head and Neck
• Index.