Hypoxia and Cancer Biological Implications and Therapeutic Opportunities /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Melillo, Giovanni (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2014.
• Σειρά: Cancer Drug Discovery and Development,
• Θέματα: Medicine.; Cancer research.; Molecular biology.; Pharmacology.; Stem cells.; Biomedicine.; Cancer Research.; Molecular Medicine.; Pharmacology/Toxicology.; Stem Cells.

The tremendous progress in our understanding of the molecular mechanisms underlying tumor hypoxias has generated a great deal of enthusiasm and provides new opportunities to better understand and target the tumor microenvironment. This book emphasizes how changes in oxygen levels in the tumor microe...

Πίνακας περιεχομένων:

• Preface
• Hypoxia and breast cancer metastasis
• Hypoxia and the DNA damage response
• Hypoxia and non-coding RNAs
• Hypoxia and ROS
• Hypoxia and gene expression
• Carbonic anhydrase IX: from biology to therapy
• Imaging the hypoxic tumor microenvironment in preclinical models
• Clinical imaging of hypoxia
• Hypoxia, antiangiogenic therapy and metastasis
• UPR and therapeutic opportunities
• Targeting the hypoxic phenotype
• Marianne Nordsmark: Hypoxia and Radiation therapy
• Pharmacological strategies targeting hypoxia
• Targeting the hypoxic tumor microenvironment
• Clinical exploitation of hypoxia
• Index.