Hypoxia and Cancer Biological Implications and Therapeutic Opportunities /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Melillo, Giovanni (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2014.
• Series: Cancer Drug Discovery and Development,
• Subjects: Medicine.; Cancer research.; Molecular biology.; Pharmacology.; Stem cells.; Biomedicine.; Cancer Research.; Molecular Medicine.; Pharmacology/Toxicology.; Stem Cells.

The tremendous progress in our understanding of the molecular mechanisms underlying tumor hypoxias has generated a great deal of enthusiasm and provides new opportunities to better understand and target the tumor microenvironment. This book emphasizes how changes in oxygen levels in the tumor microe...

Table of Contents:

• Preface
• Hypoxia and breast cancer metastasis
• Hypoxia and the DNA damage response
• Hypoxia and non-coding RNAs
• Hypoxia and ROS
• Hypoxia and gene expression
• Carbonic anhydrase IX: from biology to therapy
• Imaging the hypoxic tumor microenvironment in preclinical models
• Clinical imaging of hypoxia
• Hypoxia, antiangiogenic therapy and metastasis
• UPR and therapeutic opportunities
• Targeting the hypoxic phenotype
• Marianne Nordsmark: Hypoxia and Radiation therapy
• Pharmacological strategies targeting hypoxia
• Targeting the hypoxic tumor microenvironment
• Clinical exploitation of hypoxia
• Index.