Design, Analysis, and Interpretation of Genome-Wide Association Scans

• Κύριος συγγραφέας: Stram, Daniel O. (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2014.
• Σειρά: Statistics for Biology and Health,
• Θέματα: Statistics.; Human genetics.; Statistics for Life Sciences, Medicine, Health Sciences.; Human Genetics.; Statistical Theory and Methods.

This book presents the statistical aspects of designing, analyzing and interpreting the results of genome-wide association scans (GWAS studies) for genetic causes of disease using unrelated subjects. Particular detail is given to the practical aspects of employing the bioinformatics and data handlin...

Πίνακας περιεχομένων:

• Introduction to Genome-Wide Association Studies
• Topics of Quantitative Genetics
• An Introduction to Association Studies
• Correcting for Hidden Population Structure in Single Marker Association Testing and Estimation
• Haplotype Imputation for Association Analysis
• SNP Imputation for Association Studies
• Design of Large-scale Genetic Association Studies, Sample Size and Power
• Post-GWAS Analyses.