Design, Analysis, and Interpretation of Genome-Wide Association Scans

• Main Author: Stram, Daniel O. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2014.
• Series: Statistics for Biology and Health,
• Subjects: Statistics.; Human genetics.; Statistics for Life Sciences, Medicine, Health Sciences.; Human Genetics.; Statistical Theory and Methods.

This book presents the statistical aspects of designing, analyzing and interpreting the results of genome-wide association scans (GWAS studies) for genetic causes of disease using unrelated subjects. Particular detail is given to the practical aspects of employing the bioinformatics and data handlin...

Table of Contents:

• Introduction to Genome-Wide Association Studies
• Topics of Quantitative Genetics
• An Introduction to Association Studies
• Correcting for Hidden Population Structure in Single Marker Association Testing and Estimation
• Haplotype Imputation for Association Analysis
• SNP Imputation for Association Studies
• Design of Large-scale Genetic Association Studies, Sample Size and Power
• Post-GWAS Analyses.