Molecular Aspects of Botulinum Neurotoxin

• Corporate Author: SpringerLink (Online service)
• Other Authors: Foster, Keith A. (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2014.
• Series: Current Topics in Neurotoxicity ; 4
• Subjects: Medicine.; Molecular biology.; Pharmacology.; Neurology.; Biomedicine.; Molecular Medicine.; Pharmacology/Toxicology.; Biomedicine general.

Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense application...

Table of Contents:

• Overview and history of botulinum neurotoxin research and exploitation
• Pharmacology of botulinum neurotoxins
• Absorption and transport of botulinum neurotoxins
• The botulinum neurotoxin complex and the role of ancillary proteins
• Neurotoxin structure
• The dual receptor recognition of botulinum neurotoxins
• Translocation, entry into the cell
• Protease activity of the botulinum neurotoxins
• Molecular basis for persistence of botulinum neurotoxins
• Clostridium botulinum genomes and genetic diversity
• Botulinum neurotoxin risks and detection in environment, agriculture and food chains
• Botulism as a disease of humans
• Prevention and treatment of botulism.