Tumor Metabolome Targeting and Drug Development

• Corporate Author: SpringerLink (Online service)
• Other Authors: Kanner, Steven (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2014.
• Series: Cancer Drug Discovery and Development,
• Subjects: Medicine.; Cancer research.; Molecular biology.; Pharmacology.; Metabolism.; Biomedicine.; Cancer Research.; Metabolomics.; Molecular Medicine.; Pharmacology/Toxicology.

In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism.  The metabolic network in cells promotes the generation of both energy and bi...

Table of Contents:

• Tumor cell metabolic reprogramming and drug targeting
• Cancer metabolism: a nexus of matter, energy and reactive oxygen species
• Regulating mitochondrial respiration in cancer
• Regulation of cancer cell metabolism by hypoxia
• Glucose metabolism and the anti-oxidative defence system in cancer cells: Options for application of ROS-based anticancer drugs
• Modulating autophagy and the “reverse Warburg effect”
• Metabolic adaptation in reprogrammed cancer cells
• Index.