Obesity and Breast Cancer The Role of Dysregulated Estrogen Metabolism /

• Main Authors: Brown, Kristy A. (Author), Simpson, Evan R. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2014.
• Series: SpringerBriefs in Cancer Research
• Subjects: Medicine.; Cancer research.; Metabolic diseases.; Enzymology.; Biomedicine.; Cancer Research.; Metabolic Diseases.

Obesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-depend...

Table of Contents:

• Introduction
• Estrogens, adiposity and the menopause
• The link between obesity and breast cancer: Epidemiological evidence
• Adipose-derived and obesity-related factors and breast cancer
• Estrogen biosynthesis
• Therapies aimed at breaking the linkage between obesity and breast cancer
• Conclusions.