Tumor-Induced Immune Suppression Mechanisms and Therapeutic Reversal /

Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer  and therapeutic approaches to their correction. This includes the number of novel mechanisms tha...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Άλλοι συγγραφείς: Gabrilovich, Dmitry I. (Επιμελητής έκδοσης), Hurwitz, Arthur Andrew (Επιμελητής έκδοσης)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2014.
Έκδοση:2nd ed. 2014.
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
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245 1 0 |a Tumor-Induced Immune Suppression  |h [electronic resource] :  |b Mechanisms and Therapeutic Reversal /  |c edited by Dmitry I. Gabrilovich, Arthur Andrew Hurwitz. 
250 |a 2nd ed. 2014. 
264 1 |a New York, NY :  |b Springer New York :  |b Imprint: Springer,  |c 2014. 
300 |a XIV, 464 p. 38 illus., 34 illus. in color.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
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505 0 |a Preface.- Regulatory T Cells and Cancer -- Th17 cells in cancer -- Mast cells and immune response in cancer -- Myeloid-Derived Suppressor Cells in Tumor-Induced T-Cell Suppression and Tolerance -- Immunobiology of Dendritic Cells in Cancer -- Macrophages and Tumor Development -- Angiogenesis and Immune Suppression in Cancer -- Tim-3 Regulation of Cancer Immunity.- Transcriptional Regulation of Dendritic Cells in The Tumor Microenvironment -- S100A9, Inflammation, and Regulation of Immune Suppression in Cancer -- IDO in Inflammatory Programming and Immune Suppression in Cancer -- Defining the Fate and Function of Effector T cells through Galectin-1 – Galectin-1 Ligand Binding Interactions: Implications in Tumor Immunity -- Arginine Metabolism, a Major Pathway for the Suppressive Function of Myeloid-derived Suppressor Cells.- The Hypoxia-Adenosinergic Immunosuppression and Redirection of Immune Response in Tumor Microenvironment -- Molecular Pathways in Antigen Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance -- Overcoming Immune Suppression: Therapeutic Strategies Targeting T-Cell Function in Cancer -- Index. 
520 |a Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer  and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs. The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy  to provide breakthroughs in cancer treatment.  It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance,  but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune  suppression to make any progress in the field and this monograph provides these important insights. 
650 0 |a Medicine. 
650 0 |a Cancer research. 
650 0 |a Human genetics. 
650 0 |a Immunology. 
650 0 |a Medical microbiology. 
650 0 |a Cell biology. 
650 0 |a Developmental biology. 
650 1 4 |a Biomedicine. 
650 2 4 |a Cancer Research. 
650 2 4 |a Immunology. 
650 2 4 |a Medical Microbiology. 
650 2 4 |a Cell Biology. 
650 2 4 |a Human Genetics. 
650 2 4 |a Developmental Biology. 
700 1 |a Gabrilovich, Dmitry I.  |e editor. 
700 1 |a Hurwitz, Arthur Andrew.  |e editor. 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer eBooks 
776 0 8 |i Printed edition:  |z 9781489980557 
856 4 0 |u http://dx.doi.org/10.1007/978-1-4899-8056-4  |z Full Text via HEAL-Link 
912 |a ZDB-2-SBL 
950 |a Biomedical and Life Sciences (Springer-11642)