Gene Therapy for HIV From Inception to a Possible Cure /

• Main Authors: Bauer, Gerhard (Author), Anderson, Joseph S. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2014.
• Series: SpringerBriefs in Biochemistry and Molecular Biology,
• Subjects: Medicine.; Gene therapy.; Immunology.; Vaccines.; Virology.; Biomedicine.; Gene Therapy.; Vaccine.

This Brief describes the concept and realization of gene therapy for HIV from the unique historic perspective and insight of two pioneers of the clinical applications of stem cell gene therapy for HIV. Gerhard Bauer applied ribozyme-anti-HIV and other vectors to manufacture clinical grade, HIV-resis...

Table of Contents:

• Principles of Gene Therapy
• Injection of Naked DNA
• Non-Viral Gene Transfer (Transfection) Methods
• Viral gene transfer (transduction) methods
• Retroviruses
• Other viruses.- History of Gene Therapy.- Principles of HIV Gene Therapy.- Gene Therapy Vectors.- Lentiviral vectors.- Other modifications and additions.- Anti-HIV genes.- RNA-strategies.- Vector production.- Stem Cells for HIV Gene Therapy.- Pluripotent stem cells.- Animal Models Used in HIV Gene Therapy
• Murine models.- HIV infections in humanized mice.- Non-human primates.- Manufacturing of a GMP grade product for HIV gene therapy.- Clinical applications of HIV gene therapy.-  Clinical trials of T cell gene therapy.- Stem cell gene therapy clinical trials for HIV.- Is A Cure for HIV Possible?.