Cardiac Energy Metabolism in Health and Disease

The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP.  The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy, and any change...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Άλλοι συγγραφείς: Lopaschuk, Gary D. (Επιμελητής έκδοσης), Dhalla, Naranjan S. (Επιμελητής έκδοσης)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2014.
Σειρά:Advances in Biochemistry in Health and Disease ; 11
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
Πίνακας περιεχομένων:
  • Part 1. Control of Energy Metabolism
  • 1. A Primer on Carbohydrate Metabolism in the Heart
  • 2. Lipoproteins: A Source of Cardiac Lipids
  • 3. Role of Lipoprotein Lipase in Fatty Acid Delivery to the Heart
  • 4. Control of Myocardial Fatty Acid Uptake
  • 5. Cardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetes
  • 6. Transcriptional Control of Mitochondrial Biogenesis and Maturation
  • 7. Relationship between Substrate Metabolism and Cardiac Efficiency
  • 8. Acetylation in the Control of Mitochondrial Metabolism and Integrity
  • Part 2. Alteration in Energy Metabolism
  • 9. Adrenergic Control of Cardiac Fatty Acid Oxidation in Diabetes
  • 10. The Myocardial Creatine Kinase System in the Normal, Ischaemic and Failing Heart
  • 11. Fuel Metabolism Plasticity in Pathological Cardiac Hypertrophy and Failure
  • 12. Defects in Mitochondrial Oxidative Phosphorylation in Hearts Subjected to Ischemia-Reperfusion Injury
  • 13. The Role of AMPK in the Control of Cardiac Hypertrophy
  • 14. The Role of Incomplete Fatty Acid Oxidation in the Development of Cardiac Insulin Resistance
  • Part 3. Optimization of Energy Metabolism
  • 15. Metabolic Therapy for the Ischemic Heart
  • 16. Inhibition of Fatty Acid Oxidation to Treat Heart Failure in Patients
  • 17. Cardiac Metabolic Protection for the Newborn Heart
  • 18. Targeting Transcriptional Control of Fatty Acid Oxidation to Treat Heart Disease.