Topical Drug Bioavailability, Bioequivalence, and Penetration

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Shah, Vinod P. (Επιμελητής έκδοσης), Maibach, Howard I. (Επιμελητής έκδοσης), Jenner, John (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2014.
• Έκδοση: 2nd ed. 2014.
• Θέματα: Medicine.; Pharmacology.; Animal physiology.; Biophysics.; Biological physics.; Biomedicine.; Pharmacology/Toxicology.; Animal Physiology.; Biophysics and Biological Physics.

This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics incl...

Πίνακας περιεχομένων:

• 1 Percutaneous Absorption
• 2 Animal Models for Percutaneous Absorption
• 3 Mitigating Dermal Exposure to Agrochemicals
• 4 Importance of In Vitro Drug Release
• 5 Diffusion Cell Design
• 6 In Vitro Product Quality Tests and Product Performance Tests for Topical and Transdermal Drug Products
• 7 Safety and efficacy testing of topical products; Practical considerations
• 8 Challenges in Evaluating Bioequivalence of Topical Dermatological Drug Products
• 9 Methods for the Assessment of Bioequivalence of Topical Dosage Forms: Correlations, Optimization Strategies and Innovative Approaches
• 10 Application of Microdialysis in Assessing Cutaneous Bioavailability
• 11 Follicular Drug Penetration
• 12 Development of Pilosebaceous Unit-Targeted Drug Products
• 13 Deep Percutaneous Penetration into Muscles and Joints: Update
• 14 Efficacy & Toxicity of Microneedle based devices
• 15 Mathematical Models for Topical and Transdermal Drug Products
• 16 Transdermal Patches: An Industrial Perspective on the Relevance of in vitro Skin Permeation Studies and Approaches on Design of Manufacturing Processes
• 17 Transdermal Drug Delivery Systems.  Regulatory Considerations:  NDA and ANDA Requirements
• 18 Transdermal Estradiol and Testosterone Transfer in Man: Existence, Models, and Strategies for Prevention
• 19 Effects of occlusion on dermal drug delivery: implications for bioequivalence measurement
• 20 Challenges with Clinical Endpoints – Bioequivalence
• 21 Clinical Considerations of Bioequivalence For Topical Dermatologic Drugs
• 22 OECD Test Guideline 428 – A method for in vitro percutaneous absorption measurement?
• 23 Bioequivalence, Quality, and Novel Assessment Technologies for Topical Products: Current Challenges and Future Prospects.