Extrasynaptic GABAA Receptors

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Errington, Adam C. (Επιμελητής έκδοσης), Di Giovanni, Giuseppe (Επιμελητής έκδοσης), Crunelli, Vincenzo (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2014.
• Σειρά: The Receptors ; 27
• Θέματα: Medicine.; Neurosciences.; Pharmacology.; Neurology.; Biomedicine.; Pharmacology/Toxicology.

GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhib...

Πίνακας περιεχομένων:

• A brief introduction to extrasynaptic GABAA receptors and ‘tonic’ GABAA receptor mediated inhibition in physiology and disease
• Extrasynaptic GABAA receptors: subunit composition, distribution, and regulation
• Biophysical properties of recombinant 2- AND δ- subunit containing GABAA receptors
• The pharmacology of extrasynaptic GABAA receptors
• Neurosteroids and extrasynaptic GABAA receptors
• Sources of GABA that activate extrasynaptic GABAA receptors
• Modulation of Extrasynaptic GABAA Receptors by G-protein-coupled Receptors
• Extrasynaptic GABAA receptors and tonic inhibition in spinal cord
• The role of peri-synaptic GABA receptors after stroke
• The role of extrasynaptic GABAA receptors in focal epilepsy
• Gain-of-Function of Thalamic Extrasynaptic GABA-A Receptors in Typical Absence Seizures
• GABAergic control of the hypothalamic-pituitary-adrenal (HPA) axis: role of extrasynaptic GABAA receptors
• Tonic GABAA receptor mediated inhibition in Fragile-X Syndrome: A cause of dysfunction or a pathway for a cure?