Molecular Genetics of Dysregulated pH Homeostasis

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Chi, Jen-Tsan Ashley (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2014.
• Θέματα: Medicine.; Human genetics.; Cell biology.; Biomedicine.; Human Genetics.; Cell Biology.; Biomedicine general.

Most biological reactions and functions occur within a narrow range of pH. Any changes in the pH have great impacts on the biological function at every level, including protein folding, enzymatic activities and proliferation, and cell death. Therefore, maintaining the pH homeostasis at the local or...

Πίνακας περιεχομένων:

• Molecular Genetics of Acid Sensing and Response
• Part I: Sensing Acidity
• The molecular mechanism of cellular sensing of acidity
• The Molecular Basis of Sour Sensing in Mammals
• Function and Signaling of the pH-sensing G protein-coupled receptors in physiology and diseases
• Part II: Response to Acidity
• The MondoA-TXNIP checkpoint couples the acidic tumor microenvironment to cell metabolism
• Regulation of Renal Glutamine Metabolisms during Metabolic Acidosis
• Extracellular acidosis and cancer
• The genomic analysis of cellular responses and adaptions to extracellular acidosis
• Index.