Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease

Receptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade have become the number one targets of cancer drugs. Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease systematically covers, for the first ti...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Άλλοι συγγραφείς: Wheeler, Deric L. (Επιμελητής έκδοσης), Yarden, Yosef (Επιμελητής έκδοσης)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2015.
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
LEADER 02937nam a22004695i 4500
001 978-1-4939-2053-2
003 DE-He213
005 20151204164537.0
007 cr nn 008mamaa
008 141126s2015 xxu| s |||| 0|eng d
020 |a 9781493920532  |9 978-1-4939-2053-2 
024 7 |a 10.1007/978-1-4939-2053-2  |2 doi 
040 |d GrThAP 
050 4 |a QH573-671 
072 7 |a PSF  |2 bicssc 
072 7 |a SCI049000  |2 bisacsh 
082 0 4 |a 571.6  |2 23 
245 1 0 |a Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease  |h [electronic resource] /  |c edited by Deric L. Wheeler, Yosef Yarden. 
264 1 |a New York, NY :  |b Springer New York :  |b Imprint: Springer,  |c 2015. 
300 |a XVII, 440 p. 56 illus., 51 illus. in color.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
505 0 |a The Eukaryotic Protein Kinase Superfamily -- Evolution of Receptor Tyrosine Kinases -- RTKs in Invertebrates: Lessons in Signal Transduction -- Cell Signaling by Receptor Tyrosine Kinases -- Nuclear Signaling of Receptor Tyrosine Kinases -- Computational and Modeling Aspects of RTK Networks -- Endocytosis of Receptor Tyrosine Kinases -- Structural Features of the Ligand-Binding Extracellular Domain -- Structural Features of the Kinase Domain -- Targeting RTKs in Cancer.-  Mouse Models of Receptor Tyrosine Kinases. 
520 |a Receptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade have become the number one targets of cancer drugs. Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease systematically covers, for the first time, the shared structural and functional features of the RTK family. Understanding the evolutionary origin of the 58 RTKs, their roles in invertebrates and in humans, as well as downstream signaling pathways, is essential for fundamental research and for attempts to develop pharmacological agents able to enhance or intercept their actions. The assembly of chapters written by experts underscores commonalities and is an ideal companion volume to The Receptor Tyrosine Kinase Family, which refers to specific subfamilies of RTKs, along with their unique landmarks. 
650 0 |a Life sciences. 
650 0 |a Cancer research. 
650 0 |a Proteins. 
650 0 |a Cell biology. 
650 1 4 |a Life Sciences. 
650 2 4 |a Cell Biology. 
650 2 4 |a Receptors. 
650 2 4 |a Cancer Research. 
700 1 |a Wheeler, Deric L.  |e editor. 
700 1 |a Yarden, Yosef.  |e editor. 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer eBooks 
776 0 8 |i Printed edition:  |z 9781493920525 
856 4 0 |u http://dx.doi.org/10.1007/978-1-4939-2053-2  |z Full Text via HEAL-Link 
912 |a ZDB-2-SBL 
950 |a Biomedical and Life Sciences (Springer-11642)