Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease

• Corporate Author: SpringerLink (Online service)
• Other Authors: Wheeler, Deric L. (Editor), Yarden, Yosef (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2015.
• Subjects: Life sciences.; Cancer research.; Proteins.; Cell biology.; Life Sciences.; Cell Biology.; Receptors.; Cancer Research.

Receptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade have become the number one targets of cancer drugs. Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease systematically covers, for the first ti...

Table of Contents:

• The Eukaryotic Protein Kinase Superfamily
• Evolution of Receptor Tyrosine Kinases
• RTKs in Invertebrates: Lessons in Signal Transduction
• Cell Signaling by Receptor Tyrosine Kinases
• Nuclear Signaling of Receptor Tyrosine Kinases
• Computational and Modeling Aspects of RTK Networks
• Endocytosis of Receptor Tyrosine Kinases
• Structural Features of the Ligand-Binding Extracellular Domain
• Structural Features of the Kinase Domain
• Targeting RTKs in Cancer.-  Mouse Models of Receptor Tyrosine Kinases.