BRAF Targets in Melanoma Biological Mechanisms, Resistance, and Drug Discovery /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Sullivan, Ryan J. (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2015.
• Series: Cancer Drug Discovery and Development, 82
• Subjects: Medicine.; Cancer research.; Medical microbiology.; Molecular biology.; Pharmacology.; Biomedicine.; Cancer Research.; Molecular Medicine.; Medical Microbiology.; Pharmacology/Toxicology.

This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF...

Table of Contents:

• Melanoma: Historical Context
• Melanoma Pathogenesis
• Molecular Diagnostics and Tumor Mutational Analysis
• Clinical Utility of BRAF-targeted therapy in Melanoma
• The Ethics of Randomized Trials in Oncology
• Parallel and Serial Blockade Strategies in BRAF-Mutant Melanoma
• Targeting the cell cycle and p53 in combination with BRAF-directed therapy
• Combination BRAF-directed therapy and immunotherapy
• Moving Forward: Making BRAF-Targeted Therapy Better.