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03647nam a22005775i 4500 |
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978-1-4939-5617-3 |
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DE-He213 |
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20160810153448.0 |
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cr nn 008mamaa |
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160810s2016 xxu| s |||| 0|eng d |
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|a 9781493956173
|9 978-1-4939-5617-3
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|a 10.1007/978-1-4939-5617-3
|2 doi
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|a QP34-38
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|a MED075000
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|a 612
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|a Molecular and Cellular Mechanobiology
|h [electronic resource] /
|c edited by Shu Chien, Adam J. Engler, Peter Yingxiao Wang.
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| 264 |
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|a New York, NY :
|b Springer New York :
|b Imprint: Springer,
|c 2016.
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| 300 |
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|a XIII, 302 p. 58 illus., 57 illus. in color.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a text file
|b PDF
|2 rda
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| 490 |
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|a Physiology in Health and Disease
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|a Part 1. Mechanosensors -- The Primary Cilium as a Strain Amplifying Microdomain for Mechanotransduction at the Cell Membrane -- Vascular Endothelial Mechanosensors in Response to Fluid Shear Stress -- Cadherins in Mechanotransduction -- Perspectives of FRET Imaging to study Epigenetics and Mechanobiology in the Nucleus -- Part 2. Transducers -- Emerging Roles of YAP/TAZ in Mechanobiology -- Role of Rho GTPases in Mechanobiology -- Illuminating Cell Adhesion: Modern Microscopy Approaches to Study Integrin-Based Focal Adhesions -- Part 3. Epigenetic and Genetic Regulations in the Nucleus -- Mechanotransduction to Epigenetic Remodeling -- The Nuclear Lamina: From Mechano-Sensing in Differentiation to Cancer Cell Migration -- Role of Cell Geometry on Nuclear Mechanics, Chromosome Reorganization, and Gene Expression -- Part 4. Applications -- Mechanobiological Control of Cell Fate for Applications in Cardiovascular Regenerative Medicine -- Heart Valve Mechanobiology in Development and Disease -- Molecular and Cellular Mechanobiology of Cancer.
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| 520 |
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|a This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.
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| 650 |
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|a Medicine.
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| 650 |
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|a Human physiology.
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| 650 |
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|a Molecular biology.
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| 650 |
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|a Proteins.
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| 650 |
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|a Cell physiology.
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| 650 |
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|a Atomic structure.
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| 650 |
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|a Molecular structure.
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| 650 |
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|a Spectra.
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| 650 |
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4 |
|a Biomedicine.
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| 650 |
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4 |
|a Human Physiology.
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| 650 |
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4 |
|a Cell Physiology.
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| 650 |
2 |
4 |
|a Atomic/Molecular Structure and Spectra.
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| 650 |
2 |
4 |
|a Protein Science.
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| 650 |
2 |
4 |
|a Molecular Medicine.
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| 700 |
1 |
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|a Chien, Shu.
|e editor.
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| 700 |
1 |
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|a Engler, Adam J.
|e editor.
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| 700 |
1 |
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|a Wang, Peter Yingxiao.
|e editor.
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| 710 |
2 |
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|a SpringerLink (Online service)
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| 773 |
0 |
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|t Springer eBooks
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| 776 |
0 |
8 |
|i Printed edition:
|z 9781493956159
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| 830 |
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|a Physiology in Health and Disease
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| 856 |
4 |
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|u http://dx.doi.org/10.1007/978-1-4939-5617-3
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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