Molecular and Cellular Mechanobiology

• Corporate Author: SpringerLink (Online service)
• Other Authors: Chien, Shu (Editor), Engler, Adam J. (Editor), Wang, Peter Yingxiao (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2016.
• Series: Physiology in Health and Disease
• Subjects: Medicine.; Human physiology.; Molecular biology.; Proteins.; Cell physiology.; Atomic structure.; Molecular structure.; Spectra.; Biomedicine.; Human Physiology.; Cell Physiology.; Atomic/Molecular Structure and Spectra.; Protein Science.; Molecular Medicine.

This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across differe...

Table of Contents:

• Part 1. Mechanosensors
• The Primary Cilium as a Strain Amplifying Microdomain for Mechanotransduction at the Cell Membrane
• Vascular Endothelial Mechanosensors in Response to Fluid Shear Stress
• Cadherins in Mechanotransduction
• Perspectives of FRET Imaging to study Epigenetics and Mechanobiology in the Nucleus
• Part 2. Transducers
• Emerging Roles of YAP/TAZ in Mechanobiology
• Role of Rho GTPases in Mechanobiology
• Illuminating Cell Adhesion: Modern Microscopy Approaches to Study Integrin-Based Focal Adhesions
• Part 3. Epigenetic and Genetic Regulations in the Nucleus
• Mechanotransduction to Epigenetic Remodeling
• The Nuclear Lamina: From Mechano-Sensing in Differentiation to Cancer Cell Migration
• Role of Cell Geometry on Nuclear Mechanics, Chromosome Reorganization, and Gene Expression
• Part 4. Applications
• Mechanobiological Control of Cell Fate for Applications in Cardiovascular Regenerative Medicine
• Heart Valve Mechanobiology in Development and Disease
• Molecular and Cellular Mechanobiology of Cancer.