Discoidin Domain Receptors in Health and Disease

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Fridman, Rafael (Επιμελητής έκδοσης), Huang, Paul H. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2016.
• Θέματα: Medicine.; Cancer research.; Medical microbiology.; Medical biochemistry.; Cell biology.; Biomedicine.; Cancer Research.; Medical Microbiology.; Medical Biochemistry.; Cell Biology.

The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which event...

Πίνακας περιεχομένων:

• Part I: Discoidin Domain Receptor biology and roles in physiology
• DDRs: Binding properties, cell adhesion and modulation of integrin function
• DDRs and collagen fibrillogenesis
• DDR Structural Biology
• DDR Mouse models
• DDR in Invertebrates
• Part II: Discoidin Domain Receptors in Cancer
• Discoidin Domain Receptors and Disease
• Discoidin Domain Receptors in Normal Mammary Development and Breast Cancer Progression
• Discoidin Domain Receptors in Lung Cancer
• DDRs in healthy and cancerous reproductive systems
• Small Molecule Inhibitors of Discoidin Domain Receptors
• Discoidin Domain Receptor Signaling Networks
• Discoidin Domain Receptor Signaling and Pharmacological Inhibitors
• Functions of DDR1 in epithelial cell differentiation
• Part III: Discoidin Domain Receptors in other pathologies
• Discoidin Domain Receptor 2 in Development of Osteoarthritis
• DDR1 in Renal Function and Disease
• Discoidin Domain Receptors in Liver Fibrosis
• The role of DDRs in Atherosclerosis
• Discoidin Domain Receptors in Cardiac Development.