Frontiers in Cancer Research Evolutionary Foundations, Revolutionary Directions /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Maley, Carlo C. (Editor), Greaves, Mel (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2016.
• Subjects: Medicine.; Cancer research.; Pharmacology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.

This is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diversity within tumors (intra-tumor heterogeneity...

Table of Contents:

• 1. The Evolutionary Foundations of Cancer Research
• 2. The Role of Theory in Cancer Research
• 3. Population Genetics of Neoplasms
• 4. Diversity in Neoplasms
• 5. How do Mutant Clones Expand in Normal Tissue?
• 6. Cancer Stem Cells in Tumor Evolution
• 7. Measuring Rather than Imagining Somatic Cell Selection and Clonal Evolution
• 8. The Darwinian Dynamics of Motility and Metastasis
• 9. Applying Evolutionary Principles to Cancer Therapy
• 10. Mismatches with Our Ancestral Environments and Cancer Risk
• 11. The Evolution of Cancer Suppression Mechanisms
• 12. Epilogue: How can we Thwart the Evolutionary Resilience of Cancer?.