Targeting Notch in Cancer From the Fruit Fly to the Clinic /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Miele, Lucio (Editor, http://id.loc.gov/vocabulary/relators/edt), Artavanis-Tsakonas, Spyros (Editor, http://id.loc.gov/vocabulary/relators/edt)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2018.
• Edition: 1st ed. 2018.
• Subjects: Cancer research.; Pharmacology.; Cancer Research.; Pharmacology/Toxicology.

The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis...

Table of Contents:

• Structural Biology of Notch Signaling
• Non-Canonical Notch Signaling
• Dual Function of Notch Signaling in Cancer - Oncogene and Tumorsuppressor
• Out on the Fringe: Modulation of Notch Signaling by Glycosylation
• Notch signaling: A pivot regulator of adaptive and innate immunity
• Notch in Ovarian Cancer
• Notch Signaling in Graft-versus-Host Disease
• Notch Signaling in T-Cell Acute Lymphoblastic Leukemia and Other Hematologic Malignancies
• The Role of Notch in Breast Cancer
• Notch in Lung Cancer
• Notch Signaling in Pediatric Soft tissue Sarcoma
• Notch Ligands in Hematopoietic Stem Cell production
• Notch Signaling in the normal intestine and intestinal Cancer
• Notch Signaling in Estrogen-Dependent Cancers
• Index.