Combination Cancer Therapy Modulators and Potentiators /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Schwartz, Gary K. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Totowa, NJ : Humana Press, 2005.
• Series: Cancer Drug Discovery and Development
• Subjects: Medicine.; Oncology.; Medicine & Public Health.

Early clinical trials of the new molecular-based anticancer agents have shown that many are marginal in controlling cancer, but prove to be potent modulators and potentiators of chemotherapy-induced apoptosis when used in combination with classic cytotoxic drugs or radiation. In Combination Cancer T...

Table of Contents:

• Targeting of the EGFR As a Modulator of Cancer Chemotherapy
• Cyclin-Dependent Kinase Inhibitors in Combination Chemotherapy
• Development of Protein Kinase C and Cyclin-Dependent Kinase Inhibitors As Potentiators of Cytotoxic Drug Action in Leukemia
• Carboxyamidotriazole, an Inhibitor of Nonvoltage-Operated Calcium Entry
• Targeted ?-Particle Therapy
• Pharmacological Modulation of Fluoropyrimidines
• Development of Inhibitors of HER2 With Taxanes
• Targeting NF-?B to Increase the Activity of Cisplatin in Solid Tumors
• Combinations of Chemotherapy and G3139, an Antisense Bcl-2 Oligonucleotide
• Use of Animal Models to Evaluate Signal Transduction Inhibitors As Modulators of Cytotoxic Therapy.