The Orexin/Hypocretin System Physiology and Pathophysiology /

Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatment...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Άλλοι συγγραφείς: Nishino, Seiji (Επιμελητής έκδοσης), Sakurai, Takeshi (Επιμελητής έκδοσης)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: Totowa, NJ : Humana Press, 2005.
Σειρά:Contemporary Clinical Neuroscience
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
Πίνακας περιεχομένων:
  • History
  • History and Overview of Orexin/Hypocretin Research
  • Overview of the Orexin/Hypocretin Neuronal System
  • Orexin and Orexin Receptors
  • Orexin Projections and Localization of Orexin Receptors
  • Neuronal Responses to Hypocretin/Orexin
  • Afferent System of Orexin Neurons
  • Assessment of Orexin/Hypocretin Functions in Tissue and Biological Fluids
  • Hypocretin Measurements in the CSF, and Blood and Brain Tissue
  • Hypocretin Receptor-Activated G Proteins Revealed by [35S]GTP?S Autoradiography
  • Physiology
  • Orexin System and Feeding Behavior
  • Orexins and the Autonomic Nervous System
  • Neuroendocrine Role of the Orexins (Hypocretins)
  • The Orexin/Hypocretin System and Stress and Emotion
  • Physiology
  • Hypocretin as a Wakefulness Regulatory Peptide
  • Hypocretin/Orexin Tonus and Vigilance Control
  • Hypocretin System and Aminergic and Cholinergic Systems in the Control of Vigilance
  • Orexin and Hypothalamic Control of Sleep and Waking
  • Hypocretin/Orexin and Motor Function
  • Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency
  • Overview of Human Narcolepsy
  • Canine Models of Narcolepsy
  • Rodent Models of Human Narcolepsy-Cataplexy
  • Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency
  • Hypocretin Deficiency in Human Narcolepsy
  • Hypocretin Status in Neurological Disorders in Relation to Excessive Sleepiness and Cataplexy
  • Hypocretin Measures in Psychiatric Disorders
  • Neuroendocrinology of Human Narcolepsy
  • Narcolepsy and Autoimmunity
  • Pathophysiology: Narcolepsy and Orexin/Hypocretin Deficiency
  • Pharmacology of Hypocretin/Orexin Peptides and Small Molecules
  • Rescue of Narcoleptic Orexin Neuron-Ablated Mice by Ectopic Overexpression of Orexin Peptides
  • Hypocretin/Orexin Replacement Therapy in Hypocretin/Orexin-Deficient Narcolepsy.