From Melanocytes to Melanoma The Progression to Malignancy /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Hearing, Vincent J. (Επιμελητής έκδοσης), Leong, Stanley P. L. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Totowa, NJ : Humana Press, 2006.
• Θέματα: Medicine.; Oncology.; Medicine & Public Health.

Melanoma offers an excellent model for cancer biology and an opportunity to understand the progression of a normal skin cell-the melanocyte-to malignancy. In From Melanocytes to Melanoma: The Progression to Malignancy, leading researchers and clinicians join forces to explain how skin cancer develop...

Πίνακας περιεχομένων:

• Melanocyte Development and Function
• The Origin and Development of Neural Crest-Derived Melanocytes
• MITF
• MITF
• Melanocytes and the Transcription Factor Sox10
• Human Cutaneous Pigmentation
• Melanocyte Distribution and Function in Human Skin
• Melanocyte Transformation and Progression to Melanoma
• Altered Signal Transduction in Melanoma
• BRN2 in Melanocytic Cell Development, Differentiation, and Transformation
• The Dynamic Roles of Cell-Surface Receptors in Melanoma Development
• Familial Melanoma Genes, Melanocyte Immortalization, and Melanoma Initiation
• Genetic Progression From Melanocyte to Malignant Melanoma
• The Multiple Roles of the Oncogenic Protein SKI in Human Malignant Melanoma
• RB/E2F Regulation and Dual Activity in the Melanocytic System
• Melanoma Development and Pigment Cell Transformation
• The Biology and Genetics of Melanoma
• The Biology of Xeroderma Pigmentosum
• Divergent Pathways to Cutaneous Melanoma
• Pigmentation, DNA Repair, and Candidate Genes
• Low-Penetrance Genotypes, Pigmentation Phenotypes, and Melanoma Etiology
• The Biology of Melanoma Progression
• Optical Imaging Analysis of Atypical Nevi and Melanoma
• Proteomics Analysis of Melanoma Cell Lines and Cultured Melanocytes
• Primary Invasive Melanoma to Metastatic Melanoma
• Paradigm of Metastasis for Malignant Melanoma
• Repair of UV-Induced DNA Damage and Melanoma Risk
• High-Risk Factors for Melanoma Metastasis
• Role of Melanoma Inhibitory Activity in Early Development of Malignant Melanoma
• Role and Regulation of PAR-1 in Melanoma Progression
• Molecular Mechanisms of Melanoma Metastasis
• Overview of Tumor Progression in Melanoma
• The Plasticity of Melanoma Cells and Associated Clinical Implications
• The Clinical Use of Molecular Markers as Predictors of Disease Outcome and Response to Therapy in Malignant Melanoma
• The Role of DCT/TYRP2 in Resistance of Melanoma Cells to Drugs and Radiation
• How Melanoma Cells Evade Chemotherapy
• Apoptosis in Melanoma
• Role of Melanoma-Associated Antigens
• Host Responses to Melanoma
• Future Perspectives.