Histone Deacetylases Transcriptional Regulation and Other Cellular Functions /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Verdin, Eric (Editor)
• Format: Electronic eBook
• Language: English
• Published: Totowa, NJ : Humana Press, 2006.
• Series: Cancer Drug Discovery and Development
• Subjects: Medicine.; Cancer research.; Biomedicine.; Cancer Research.

The recent discoveries that established histone acetylation as a key regulatory mechanism for gene expression triggered a wave of interest in histone posttranslational modifications and led to the development of novel anticancer agents now in clinical trials. In Histone Deacetylases: Transcriptional...

Table of Contents:

• Class I Histone Deacetylases
• Histone Deacetylase 1
• Biochemistry of Multiprotein HDAC Complexes
• The Biology of HDAC3
• The Biology of HDAC8, a Unique Class I Histone Deacetylase
• Class II Histone Deacetylases
• Regulation of Muscle Gene Expression by Histone Deacetylases
• The Class IIa Histone Deacetylases
• Histone Deacetylases in the Response to Misfolded Proteins
• Class III Histone Deacetylases
• Evolution of Sirtuins From Archaea to Vertebrates
• Structure of the Sir2 Family of NAD+-Dependent Histone/Protein Deacetylases
• The Enzymology of SIR2 Proteins
• The Class III Protein Deacetylases
• Histone Deacetylase Inhibitors
• HDAC Inhibitors
• Cell Cycle Targets of Histone Deacetylase Inhibitors
• HDAC Inhibitors.