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100301s2006 xxu| s |||| 0|eng d |
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|a 9781597450805
|9 978-1-59745-080-5
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|a 10.1007/978-1-59745-080-5
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|a The Serotonin Receptors
|h [electronic resource] :
|b From Molecular Pharmacology to Human Therapeutics /
|c edited by Bryan L. Roth.
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|a Totowa, NJ :
|b Humana Press,
|c 2006.
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|b online resource.
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|a text
|b txt
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|a The Receptors
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|a Molecular Biology and Genomic Organization of G Protein-Coupled Serotonin Receptors -- Structure and Function Reveal Insights in the Pharmacology of 5-HT Receptor Subtypes -- Polymorphic and Posttranscriptional Modifications of 5-HT Receptor Structure -- Strategies for the Development of Selective Serotonergic Agents -- 5-HT Receptor Signal Transduction Pathways -- Agonist-Directed Trafficking of 5-HT Receptor-Mediated Signal Transduction -- Identification of 5-HT2 and 5-HT4 Receptor-Interacting Proteins -- 5-HT Receptor-Associated Proteins (FRAPs) -- Cellular and Subcellular Localization of Serotonin Receptors in the Central Nervous System -- Chemical Neuroanatomy of 5-HT Receptor Subtypes in the Mammalian Brain -- Modulation of the Neuronal Activity and Neurotransmitter Release by 5-HT1A and 5-HT1B/1D Receptors -- Electrophysiology of 5-HT2A Receptors and Relevance for Hallucinogen and Atypical Antipsychotic Drug Actions -- The Emergence of 5-HT2B Receptors as Targets to Avoid in Designing and Refining Pharmaceuticals -- The 5-HT3 Receptor -- 5-HT3 and 5-HT4 Receptors as Targets for Drug Discovery for Dementia -- Electrophysiological Properties of G?s-Coupled 5-HT Receptors (5-HT4, 5-HT6, 5-HT7) -- 5-HT6 Receptors as Targets for the Treatment of Cognitive Deficits in Schizophrenia -- 5-HT7 Receptors as Favorable Pharmacological Targets for Drug Discovery -- Serotonin System Gene Knockouts -- Effects of Serotonin-Related Gene Deletion on Measures of Anxiety, Depression, and Neurotransmission.
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|a The recent cloning and identification of a large number of serotonin (5-HT) receptors-a major family of therapeutic targets-holds out the possibility of developing novel, subtype-selective 5-HT receptor agonists and antagonists for use as psychiatric, cardiovascular, and neurological medications. In The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics, leading experts comprehensively examine our current understanding of the molecular and structural biology of 5-HT receptors and their pharmacological use. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction. Comprehensive and state of the art, The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics provides an illuminating "snapshot" of the 5-HT receptor field today and prospects for the future, taking it from the genomic to a systems level of understanding.
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|a Pharmacy.
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|a Pharmacy.
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|a Pharmacy.
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| 700 |
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|a Roth, Bryan L.
|e editor.
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|a SpringerLink (Online service)
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|t Springer eBooks
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|i Printed edition:
|z 9781588295682
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|a The Receptors
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|u http://dx.doi.org/10.1007/978-1-59745-080-5
|z Full Text via HEAL-Link
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|a ZDB-2-SME
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| 950 |
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|a Medicine (Springer-11650)
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