Reverse Transcriptase Inhibitors in HIV/AIDS Therapy

• Corporate Author: SpringerLink (Online service)
• Other Authors: St.Georgiev, Vassil (Editor), Skowron, Gail (Editor), Ogden, Richard (Editor), Lange, Joep M. A. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Totowa, NJ : Humana Press, 2006.
• Series: Infectious Disease
• Subjects: Medicine.; Infectious diseases.; Medicine & Public Health.; Infectious Diseases.

Despite significant pharmacological advances, the backbone of the most highly active antiretroviral therapy regimens for controlling HIV/AIDS is still a combination of reverse transcriptase inhibitors (RTIs) first discovered in the late 1980s. In Reverse Transcriptase Inhibitors in HIV/AIDS Therapy,...

Table of Contents:

• Structural Studies on HIV Reverse Transcriptase Related to Drug Discovery
• Zidovudine, Lamivudine, and Abacavir
• Stavudine, Didanosine, and Zalcitabine
• Emtricitabine
• Nucleotide Analogs
• Resistance to Nucleoside and Nucleotide Reverse Transcriptase Inhibitors
• Pharmacokinetics of Reverse Transcriptase Inhibitors
• Peripheral Neuropathy Associated With Nucleoside Reverse Transcriptase Inhibitor Therapy
• Mitochondrial Dysfunction and Nucleoside Reverse Transcriptase Inhibitor Therapy
• Mitochondrial Toxicity and Lipodystrophy
• Nevirapine
• Efavirenz
• Delavirdine
• Resistance to Non-Nucleoside Reverse Transcriptase Inhibitors
• Vertical Transmission of HIV and Therapeutic Interventions
• New Reverse Transcriptase Inhibitors in Development
• Antiretroviral Drugs for Millions.