Checkpoint Responses in Cancer Therapy

• Corporate Author: SpringerLink (Online service)
• Other Authors: Dai, Wei (Editor)
• Format: Electronic eBook
• Language: English
• Published: Totowa, NJ : Humana Press, 2008.
• Series: Cancer Drug Discovery and Development•
• Subjects: Medicine.; Cancer research.; Pharmacology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.

Extensive research has uncovered a set of molecular surveillance mechanisms – commonly called "checkpoints" – which tightly monitor cell-cycle processes. Today’s anticancer drug development has identified many of these cell-cycle checkpoint molecules as effective targets. Research now prom...

Table of Contents:

• RB-Pathway
• Targeting the p53/MDM2 Pathway for Cancer Therapy
• DNA Topoisomerases as Targets for the Chemotherapeutic Treatment of Cancer
• Targeting ATM/ATR in the DNA Damage Checkpoint
• Compounds that Abrogate the G2 Checkpoint
• CDK Inhibitors as Anticancer Agents
• CHFR as a Potential Anticancer Target
• Antimicrotubule Agents
• Kinesin Motor Inhibitors as Effective Anticancer Drugs
• Targeting the Spindle Checkpoint in Cancer Chemotherapy
• Antiproliferation Inhibitors Targeting Aurora Kinases
• Plks as Novel Targets for Cancer Drug Design
• Do Histone Deacetylase Inhibitors Target Cell Cycle Checkpoints that Monitor Heterochromatin Structure?.