Transforming Growth Factor-β in Cancer Therapy, Volume II Cancer Treatment and Therapy /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Jakowlew, Sonia B. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Totowa, NJ : Humana Press, 2008.
• Σειρά: Cancer Drug Discovery and Development
• Θέματα: Medicine.; Cancer research.; Oncology.; Pathology.; Cell biology.; Medicine & Public Health.; Cancer Research.; Cell Biology.

 Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provides a compendium of findings about the role of transforming growth factor-ß (TGF-ß) in cancer treatment and therapy. The second volume, Cancer Treatment and Therapy, is divided into three parts. Part I examines transforming growth factor-ß in developing and advanced cancers. Part II details transforming growth factor-ß in cancer treatment and therapy. Part III includes an investigation into the development of inhibitors of transforming growth factor-ß signaling for therapy. This volume’s companion, Basic and Clinical Biology, examines transforming growth factor-ß signaling in normal physiology, cancer pathobiology, normal and tumor biology, and inflammation and fibrosis. Together, Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide researchers and clinicians with a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor-ß in biology and cancer treatment. 

 Transforming Growth Factor-? In Developing and Advanced Cancers -- Transforming Growth Factor-? Signaling in Pancreas Development and Pancreatic Disease -- Role of Transforming Growth Factor-? in the Pathogenesis of Human Head and Neck Squamous Cell Carcinoma -- TGF-?, Smads and Cervical Cancer -- TGF-? Signaling and Biglycan in Pancreatic Cancer -- TGF-? Signaling in Endometrial Cancer -- TGF-? Ligands, TGF-? Receptors, and Lung Cancer -- Role of TGF-? in Osteolytic Bone Metastases -- Hormonal Regulation of Transforming Growth Factor-? in Breast Cancer -- TGF-? and Progression of Esophageal Cancer -- TGF-? and HER2/ErbB2 and Breast Cancer Progression -- TGF-? Dependent T-Cell Regulation in Colitis and Colon Cancer -- Role of Transforming Growth Factor-? in the Kidney — Physiology and Pathology -- Perturbations of TGF-? Signaling in Leukocytes as Drivers of Leukemogenesis and Epithelial Tumorigenesis -- Transforming Growth Factor-? in Brain Functions and Dysfunctions -- Inhibition of TGF-? Signaling in Multiple Myeloma and Its Bone Marrow Microenvironment -- Key Roles of TGF-? and Smad3 in Prostate Cancer -- Smad Signaling in Leukemic Growth and Differentiation: Crosstalk Between Smad and Multiple Pathways Through Activation of the TGF-? Type I Receptor -- Transforming Growth Factor-? in Cancer Treatment and Therapy -- High-Throughput Screening of Protein Interaction Networks in the TGF? Interactome: Understanding the Signaling Mechanisms Driving Tumor Progression -- Tumor Suppressor and Pro-progression Roles for TGF-? in Breast Cancer -- Tumor Suppressors p53 and TGF? Converge to Regulate the Alpha-Fetoprotein Oncodevelopmental Tumor Marker -- TGF?: Roles in DNA Damage Responses -- The Rationale for and Effects of Targeting TGF-? for Glioma Therapy -- Tumor Suppressor Functions of TGF?1 in T Cells -- Therapeutic Effects of Adenovirus-Mediated Gene Transfer of TGF-? Signal Antagonists on Undesirable Epithelial-Mesenchymal Transition and Neovascularization -- Role of TGF-? in Tumor Protection and Antitumor Immunity -- Regulation of Angiogenesis and Tumor Growth by Thrombospondin-1 -- Cancer-Associated Fibroblasts and the Role of TGF-? -- Adoptive Transfer of Tumor Reactive TGF-? Insensitive CD8+ T-cells for Cancer Therapy -- DNA Methylation and Histone Deacetylation Inhibitors as Potential Therapeutic Agents for the Reconstitution of TGF-? Signaling in Breast Cancer -- Reactive Stroma and Evolution of Tumors: Integration of Transforming Growth Factor-?, Connective Tissue Growth Factor, and Fibroblast Growth Factor-2 Activities -- TGF-? Signaling and Vascular Morphogenesis -- Aberrant Transforming Growth Factor-? Signaling in Human Pancreatic Cancer: Translational Implications -- TGF-? and Stromal Influences Over Local Tumor Invasion -- TGF-? at the Crossroads Between Inflammation, Suppression and Cancer -- Development of Inhibitors of Transforming Growth Factor-? Signaling for Therapy -- Transforming Growth Factor-? (TGF-?) Signaling Inhibitors in Cancer Therapy -- Targeting TGF-? as a Strategy to Ameliorate Intestinal Side Effects of Radiation Therapy -- Targeting Transforming Growth Factor-? in Metastasis: In Vitro and In Vivo Mechanisms -- Targeted Downregulation of TGF-?2 with AP 12009 in Tumor Therapy -- Modulating TGF-? Receptor Signaling: A Novel Approach of Cancer Therapy -- Engineering TGF-? Traps: Artificially Dimerized Receptor Ectodomains as High-affinity Blockers of TGF-? Action -- The Use of Virtual Screening in ALK5 Kinase Inhibitor Discovery and Validation of Orally Active ALK5 Kinase Inhibitors in Oncology -- Soluble Type II Transforming Growth Factor-? Receptor Inhibits Tumorigenesis by Augmenting Host Antitumor Immunity -- Reversal of EMT by Small-Molecule Inhibitors of TGF-? Type I and II Receptors: Implications for Carcinoma Treatment -- Soluble TGF-? Type III Receptor Suppresses Malignant Progression of Human Cancer Cells -- Targeting Smad-Dependent TGF-? Signaling with Peptide Aptamers -- Rationale for Anti-TGF-? Antibody Therapy in Oncology.