Acute Myelogenous Leukemia

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Karp, Judith E. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Totowa, NJ : Humana Press, 2007.
• Σειρά: Contemporary Hematology
• Θέματα: Medicine.; Cancer research.; Internal medicine.; Hematology.; Oncology.; Medicine & Public Health.; Cancer Research.; Internal Medicine.

Acute Myelogenous Leukemia is a timely compilation of new concepts in the molecular pathogenesis and molecular therapy of acute myelogenous leukemia (AML). The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by divers...

Πίνακας περιεχομένων:

• Overview of AML
• Approaching the Treatment of AML from a Biological Perspective
• Molecular Foundations of AML Pathogenesis and Physiology
• Aberrant Transcription Factors in AML
• Myelodysplasia-Related AML
• Therapy-related AML
• The DNA Damage Response, DNA Repair, and AML
• Altered Apoptosis in AML
• Drug Resistance Transporters in AML
• Translating Biology into Clinical Application
• Impact of Cytogenetics on Clinical Outcome in AML
• APL: A Classic Tale of Bench to Bedside
• Molecular Therapeutics of AML: Selected Targeted Approaches
• Emerging Therapeutics for AML
• FLT3: A Prototype Receptor Tyrosine Kinase Target in AML
• Farnesyl Transferase Inhibitors in the Therapy of AML
• Modulating Gene Expression as a Therapeutic Approach in the Treatment of AML
• Differentiation Therapy in AML
• Stem Cell Transplantation for AML
• Tumor Vaccines in Leukemia
• Special Challenges
• Treatment, Outcomes, and Challenges of Newly Diagnosed AML in Children and Adolescents
• AML in Older Adults
• Dameshek Smiles: Molecular Clues to the Chronic Myeloproliferative Disorders Unmasked
• New Designs for Clinical Trials.