mTOR Pathway and mTOR Inhibitors in Cancer Therapy

• Corporate Author: SpringerLink (Online service)
• Other Authors: Polunovsky, Vitaly A. (Editor), Houghton, Peter J. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Totowa, NJ : Humana Press : Imprint: Humana Press, 2010.
• Series: Cancer Drug Discovery and Development
• Subjects: Medicine.; Cancer research.; Pharmacology.; Cell biology.; Biomedicine.; Cancer Research.; Cell Biology.; Pharmacology/Toxicology.

mTOR Pathway and mTOR Inhibitors in Cancer Therapy provides an up-to-date survey of the rapidly advancing field of cancer therapy. Our understanding of the mechanisms involved in cancer genesis and progression underwent unprecedented expansion during the last decade, opening a new era of cancer trea...

Table of Contents:

• mTORC1: A Signaling Integration Node Involved in Cell Growth
• The Regulation of the IGF-1/mTOR Pathway by the p53 Tumor Suppressor Gene Functions
• mTOR Signaling in Angiogenesis
• mTORC1 Signaling and Hypoxia
• mTOR Signaling in Glioblastoma: Lessons Learned from Bench to Bedside
• mTOR and Cancer Therapy: General Principles
• mTOR and Cancer Therapy: Clinical Development and Novel Prospects
• Drug Combinations as a Therapeutic Approach for mTORC1 Inhibitors in Human Cancer
• Downstream Targets of mTORC1
• Downstream of mTOR: Translational Control of Cancer
• Genome-Wide Analysis of Translational Control
• Translational Control of Cancer: Implications for Targeted Therapy
• Downstream from mTOR: Therapeutic Approaches to Targeting the eIF4F Translation Initiation Complex.