Telomeres and Telomerase in Cancer

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Hiyama, Keiko (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Totowa, NJ : Humana Press, 2009.
• Σειρά: Cancer Drug Discovery and Development
• Θέματα: Medicine.; Cancer research.; Pharmacology.; Oncology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.

Telomeres and telomerase are the pivotal players that destine cellular senescence and immortalization. Telomere shortening due to "End-replication problem" in each cell cycle is a universal phenomenon for all eukaryotic cells with linear chromosomes. Its compensation by telomerase is also...

Πίνακας περιεχομένων:

• Basic Background
• Telomeres and Telomerase in Humans
• Telomere-Binding Proteins in Humans
• Regulation of Telomerase Through Transcriptional and Posttranslational Mechanisms
• Telomere Dysfunction and the DNA Damage Response
• Alternative Lengthening of Telomeres in Human Cells
• Mouse Model: Telomeres and Telomerase in Stem Cell and Cancer
• Telomeres and Telomerase in Human Cancers
• Role of Telomeres and Telomerase in Cancer
• Diagnostic Value I: Solid Tumors
• Diagnostic Value II: Hematopoietic Malignancies
• Therapeutic Targets and Drugs I: Telomerase and Telomerase Inhibitors
• Therapeutic Targets and Drugs II: G-Quadruplex and G-Quadruplex Inhibitors
• Therapeutic Targets and Drugs III: Tankyrase 1, Telomere-Binding Proteins, and Inhibitors
• Therapeutic Targets and Drugs IV: Telomerase-Specific Gene and Vector-Based Therapies for Human Cancer
• Experimental Protocols
• Protocol I: Telomerase Activity and Telomerase Expression
• Protocol II: Importance and Methods of Telomere G-Tail Length Quantification
• Protocol III: Detection of Alternative Lengthening of Telomeres.