Telomeres and Telomerase in Cancer
Telomeres and telomerase are the pivotal players that destine cellular senescence and immortalization. Telomere shortening due to "End-replication problem" in each cell cycle is a universal phenomenon for all eukaryotic cells with linear chromosomes. Its compensation by telomerase is also...
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| Format: | Electronic eBook |
| Language: | English |
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Totowa, NJ :
Humana Press,
2009.
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| Series: | Cancer Drug Discovery and Development
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| Online Access: | Full Text via HEAL-Link |
Table of Contents:
- Basic Background
- Telomeres and Telomerase in Humans
- Telomere-Binding Proteins in Humans
- Regulation of Telomerase Through Transcriptional and Posttranslational Mechanisms
- Telomere Dysfunction and the DNA Damage Response
- Alternative Lengthening of Telomeres in Human Cells
- Mouse Model: Telomeres and Telomerase in Stem Cell and Cancer
- Telomeres and Telomerase in Human Cancers
- Role of Telomeres and Telomerase in Cancer
- Diagnostic Value I: Solid Tumors
- Diagnostic Value II: Hematopoietic Malignancies
- Therapeutic Targets and Drugs I: Telomerase and Telomerase Inhibitors
- Therapeutic Targets and Drugs II: G-Quadruplex and G-Quadruplex Inhibitors
- Therapeutic Targets and Drugs III: Tankyrase 1, Telomere-Binding Proteins, and Inhibitors
- Therapeutic Targets and Drugs IV: Telomerase-Specific Gene and Vector-Based Therapies for Human Cancer
- Experimental Protocols
- Protocol I: Telomerase Activity and Telomerase Expression
- Protocol II: Importance and Methods of Telomere G-Tail Length Quantification
- Protocol III: Detection of Alternative Lengthening of Telomeres.
