Checkpoint Controls and Targets in Cancer Therapy

• Corporate Author: SpringerLink (Online service)
• Other Authors: Siddik, Zahid H. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Totowa, NJ : Humana Press, 2009.
• Edition: 1.
• Series: Cancer Drug Discovery and Development
• Subjects: Medicine.; Cancer research.; Pharmacology.; Oncology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.

There is no question that loss of cell cycle checkpoint regulation is an intrinsic characteristic of cancer. However, many tumors retain parallel checkpoint pathways that are activated by antitumor agents and facilitate therapeutic response. Failures in these therapy-linked checkpoint controls are...