New Strategies in Stroke Intervention Ionic Transporters, Pumps, and New Channels /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Annunziato, Lucio (Editor)
• Format: Electronic eBook
• Language: English
• Published: Totowa, NJ : Humana Press, 2010.
• Series: Contemporary Neuroscience
• Subjects: Medicine.; Molecular biology.; Neurosciences.; Pharmacology.; Anesthesiology.; Cardiology.; Neurology.; Biomedicine.; Molecular Medicine.; Pharmacology/Toxicology.

Ischemic brain damage represents a major source of morbidity and mortality in westernized society and poses a significant financial burden on the health care system. To date, few effective therapies have been realized to treat stroke and promising avenues have not proven clinically useful. Recent ev...

Table of Contents:

• Basis of Ionic Dysregulation in Cerebral Ischemia
• Why have Ionotropic and Metabotropic Glutamate Antagonists Failed in Stroke Therapy?
• Mitochondrial Channels as Potential Targets for Pharmacological Strategies in Brain Ischemia
• Endoplasmic Reticulum Calcium Homeostasis and Neuronal Pathophysiology of Stroke
• The Na + /Ca 2+ Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia
• The “Loop” Diuretic Drug Bumetanide-Sensitive Na + -K + -Cl - Cotransporter in Cerebral Ischemia
• The Na + /H + Exchanger: A Target for Therapeutic Intervention in Cerebral Ischemia
• The Na + /K + -ATPase as a Drug Target for Ischemic Stroke
• Acid-Sensing Ion Channels (ASICs): New Targets in Stroke Treatment
• Role of TRPM7 in Ischemic CNS Injury
• Subtypes of Voltage-Gated Ca 2+ Channels and Ischemic Brain Injury
• The Diverse Roles of K + Channels in Brain Ischemia
• Clinical Trials with Drugs Targeting Ionic Channels, Antiporters, and Pumps in Ischemic Stroke.