Protein Kinase C in Cancer Signaling and Therapy

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Kazanietz, Marcelo G. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Totowa, NJ : Humana Press : Imprint: Humana Press, 2010.
• Σειρά: Current Cancer Research
• Θέματα: Medicine.; Cancer research.; Pharmacology.; Biomedicine.; Cancer Research.; Pharmacology/Toxicology.

Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor-promoting activity. Phorbol esters had long been of interest to the cancer re...

Πίνακας περιεχομένων:

• Regulation of PKC Isozyme Function: From Genes to Biochemistry
• Protein Kinase C in Cancer Signaling and Therapy: Introduction and Historical Perspective
• Regulation of Conventional and Novel Protein Kinase C Isozymes by Phosphorylation and Lipids
• Phorbol Esters and Diacylglycerol: The PKC Activators
• Diacylglycerol Signaling: The C1 Domain, Generation of DAG, and Termination of Signals
• Regulation of PKC by Protein–Protein Interactions in Cancer
• PKC Isozymes in the Control of Cell Function
• Introduction: PKC Isozymes in the Control of Cell Function
• Regulation and Function of Protein Kinase D Signaling
• PKC and Control of the Cell Cycle
• PKC and the Control of Apoptosis
• Atypical PKCs, NF-?B, and Inflammation
• PKC Isozymes in Cancer
• Introduction: PKC and Cancer
• Protein Kinase C, p53, and DNA Damage
• PKCs as Mediators of the Hedgehog and Wnt Signaling Pathways
• PKC–PKD Interplay in Cancer
• Transgenic Mouse Models to Investigate Functional Specificity of Protein Kinase C Isoforms in the Development of Squamous Cell Carcinoma, a Nonmelanoma Human Skin Cancer
• PKC Isozymes and Skin Cancer
• PKC and Breast Cancer
• PKC and Prostate Cancer
• Protein Kinase C and Lung Cancer
• PKC Isozymes as Targets for Cancer Therapy
• PKC and Resistance to Chemotherapeutic Agents
• PKC? as a Target for Chemotherapeutic Drugs
• Atypical PKCs as Targets for Cancer Therapy.