Targeted Therapeutics in Melanoma

• Corporate Author: SpringerLink (Online service)
• Other Authors: Gajewski, Thomas F. (Editor), Hodi, F. Stephen (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2012.
• Series: Current Clinical Oncology
• Subjects: Medicine.; Cancer research.; Oncology.; Medicine & Public Health.; Cancer Research.

Melanoma is an increasingly important public health problem. Although the cause of most malignant melanomas – over-exposure to ultraviolet light – is well known, effective treatment has remained challenging. The past several years have been marked by extraordinary developments in melanoma treatment...

Table of Contents:

• Molecular targets and subtypes in melanoma
• Melanoma genomics
• Predictive biomarkers as a guide to future therapy selection in melanoma
• KIT as a therapeutic target for melanoma
• Targeted inhibition of B-Raf
• The notch and B-catenin pathways
• STAT3 and Src signaling in melanoma
• Targeting the mTOR, PI3K and AKT pathways in melanoma
• Targeting apoptotic pathways in melanoma
• Anti-angiogenesis therapy in melanoma
• Melanoma antigens recognized by T lymphocytes
• Melanoma vaccines
• Adoptive cell therapy for the treatment of metastatic melanoma
• Anti-CTLA-4 monolonal antibodies
• Anti-PD-1 and Anti-B7-H1/PD-L1 monoclonal antibodies
• Treatment of melanoma with agonist immune co-stimulatory agents
• Novel cytokines for immunotherapy of melanoma
• Modulating the tumor microenvironment.