Peroxisome Proliferator-Activated Receptors Discovery and Recent Advances /

• Κύριοι συγγραφείς: Youssef, Jihan A. (Συγγραφέας), Badr, Mostafa Z. (Συγγραφέας)
• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Totowa, NJ : Humana Press : Imprint: Humana Press, 2013.
• Θέματα: Life sciences.; Biochemistry.; Proteins.; Life Sciences.; Biochemistry, general.; Receptors.

All three peroxisome proliferator-activated receptor (PPAR) subtypes share a high degree of structural homology while exhibiting differences in function, tissue distribution, and ligand specificity. In Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances, the authors trace the...

Πίνακας περιεχομένων:

• Introduction.- History of PPAR Discovery: Peroxisomes
• Peroxisomal biogenesis and diseases
• Peroxisome proliferation.- Peroxisome Proliferator-Activated Receptors: Chromosomal location and gene polymorphism
• Protein structure
• PPAR Ligands: Endogenous ligands
• Exogenous PPAR modulators
• Tissue Distribution and Versatile Functions of PPARs: Neurological functions of PPARs.- PPARs and the cardiovascular system.- PPARs in pulmonary physiology and disease.- Gastrointestinal roles of PPARs.- PPAR functions in the liver.- Roles of PPARs in the pancreas.- PPARs in the urinary tract physiology and pathophysiology.- PPARs in the reproductive system
• Bone metabolism and PPARs.- Roles of PPARs in skeletal muscle biology.- Skin PPARs.- PPARs and Drug Metabolism
• Molecular Aspects of PPAR Actions: Posttranslational control of PPARs.- Mechanism of action.- Animal Models in PPAR Research.- Safety of PPAR Agonists.- The Future of PPAR Research.