Abeta Peptide and Alzheimer’s Disease Celebrating a Century of Research /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Barrow, Colin J. (Επιμελητής έκδοσης), Small, David H. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: London : Springer London, 2007.
• Θέματα: Medicine.; Human genetics.; Molecular biology.; Neurosciences.; Medical biochemistry.; Neurology.; Neurosurgery.; Medicine & Public Health.; Medical Biochemistry.; Molecular Medicine.; Human Genetics.

Abeta Peptide and Alzheimer’s Disease summarizes current knowledge of beta-amyloid peptide (Aß) and its role as the major culprit in Alzheimer’s Disease (AD), shown by recent advances in genetics and brain biochemistry. Written by leaders in the industrial and academic world specializing in this rap...

Πίνακας περιεχομένων:

• A Brief Introduction to the History of the ?-Amyloid Protein (A?) of Alzheimer’s Disease
• The A?centric Pathway of Alzheimer’s Disease
• The Function of the Amyloid Precursor Protein Family
• The Involvement of A? in the Neuroinflammatory Response
• Amyloid ?-Peptide(1-42), Oxidative Stress, and Alzheimer’s Disease
• Amyloid Toxicity, Synaptic Dysfunction, and the Biochemistry of Neurodegeneration in Alzheimer’s Disease
• A? Variants and Their Impact on Amyloid Formation and Alzheimer’s Disease Progression
• Copper Coordination by ?-Amyloid and the Neuropathology of Alzheimer’s Disease
• Cholesterol and Alzheimer’s Disease
• Amyloid ?-Peptide and Central Cholinergic Neurons: Involvement in Normal Brain Function and Alzheimer’s Disease Pathology
• Physiologic and Neurotoxic Properties of A? Peptides
• Impact of ?-Amyloid on the Tau Pathology in Tau Transgenic Mouse and Tissue Culture Models
• Glial Cells and A? Peptides in Alzheimer’s Disease Pathogenesis
• The Role of Presenilins in A?-Induced Cell Death in Alzheimer’s Disease
• Immunotherapeutic Approaches to Alzheimer’s Disease
• Mouse Models of Alzheimer’s Disease.