Epigenetic Aspects of Chronic Diseases

• Corporate Author: SpringerLink (Online service)
• Other Authors: Roach, Helmtrud I. (Editor), Bronner, Felix (Editor), Oreffo, Richard O.C (Editor)
• Format: Electronic eBook
• Language: English
• Published: London : Springer London : Imprint: Springer, 2011.
• Subjects: Medicine.; Human genetics.; Internal medicine.; Medical biochemistry.; Biomedicine.; Human Genetics.; Medical Biochemistry.; Internal Medicine.

Epigenetic Aspects of Chronic Diseases assembles in comprehensive form what is known about the role of epigenetics in chronic disease development. This book provides new insights into treatment, including modulation of epigenetic regulation. Each chapter gives an outline of a respective disease, exp...

Table of Contents:

• Epigenetics and Chronic Diseases: An Overview
• Techniques to Study DNA Methylation and Histone Modification
• Mechanisms of Epigenetic Gene Silencing
• Mechanisms of Epigenetic Gene Activation in Disease: Dynamics of DNA Methylation and Demethylation
• The Role of Histone Demethylases in Disease
• Autoimmune Diseases
• Epigenetics of Rheumatoid Arthritis
• DNA Methylation Changes in Osteoarthritis
• Epigenetics and Type 2 Diabetes
• Epigenetic Regulation of Asthma and Allergic Diseases
• Epigenetics in Psychiatry
• Epigenetics and Late-Onset Alzheimer’s Disease
• Epigenetic Mechanisms in the Developmental Origins of Adult Disease
• Targeting Histone Deacetylases in Chronic Obstructive Pulmonary Disease
• Clinical Trials of Epigenetic Modifiers in the Treatment of Myelodysplastic Syndrome.