Comparative Gene Finding Models, Algorithms and Implementation /

Comparative genomics is an emerging field, which is being fed by an explosion in the number of possible biological sequences. This has led to an immense demand for faster, more efficient and more robust computer algorithms to analyze this large amount of data. This unique text/reference describes th...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριος συγγραφέας: Axelson-Fisk, Marina (Συγγραφέας)
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: London : Springer London, 2010.
Σειρά:Computational Biology, 11
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
LEADER 04110nam a22004815i 4500
001 978-1-84996-104-2
003 DE-He213
005 20151204182204.0
007 cr nn 008mamaa
008 100715s2010 xxk| s |||| 0|eng d
020 |a 9781849961042  |9 978-1-84996-104-2 
024 7 |a 10.1007/978-1-84996-104-2  |2 doi 
040 |d GrThAP 
050 4 |a QH324.2-324.25 
072 7 |a PSD  |2 bicssc 
072 7 |a UB  |2 bicssc 
072 7 |a SCI056000  |2 bisacsh 
082 0 4 |a 570.285  |2 23 
100 1 |a Axelson-Fisk, Marina.  |e author. 
245 1 0 |a Comparative Gene Finding  |h [electronic resource] :  |b Models, Algorithms and Implementation /  |c by Marina Axelson-Fisk. 
264 1 |a London :  |b Springer London,  |c 2010. 
300 |a XV, 304 p.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
490 1 |a Computational Biology,  |x 1568-2684 ;  |v 11 
505 0 |a Single Species Gene Finding -- Sequence Alignment -- Comparative Gene Finding -- Gene Structure Submodels -- Parameter Training -- Implementation of a Comparative Gene Finder. 
520 |a Comparative genomics is an emerging field, which is being fed by an explosion in the number of possible biological sequences. This has led to an immense demand for faster, more efficient and more robust computer algorithms to analyze this large amount of data. This unique text/reference describes the state of the art in computational gene finding, with a particular focus on comparative approaches. Providing both an overview of the various methods that are applied in the field, and a concise guide on how computational gene finders are built, the book covers a broad range of topics from probability theory, statistics, information theory, optimization theory and numerical analysis. The text assumes the reader has some background in bioinformatics, especially in mathematics and mathematical statistics. A basic knowledge of analysis, probability theory and random processes would also aid the reader. Topics and features: Describes how algorithms and sequence alignments can be combined to improve the accuracy of gene finding Introduces the basic biological terms and concepts in genetics, and provides an historical overview of algorithm development Explores the gene features most commonly captured by a computational gene model, and describes the most important sub-models used Discusses the algorithms most commonly used for single-species gene finding Investigates approaches to pairwise and multiple sequence alignments Explains the basics of parameter training, covering a number of the different parameter estimation and optimization techniques commonly used in gene finding Illustrates how to implement a comparative gene finder, explaining the different steps and various accuracy assessment measures used to debug and benchmark the software A useful text for postgraduate students, this book provides valuable insights and examples for researchers wishing to enter the field quickly. In addition to the specific focus on the algorithmic details surrounding computational gene finding, readers obtain an introduction to the fundamentals of computational biology and biological sequence analysis, as well as an overview of the important mathematical and statistical applications in bioinformatics. Dr. Marina Axelson-Fisk is an Associate Professor at the Department of Mathematical Sciences of Chalmers University of Technology, Gothenburg, Sweden. 
650 0 |a Life sciences. 
650 0 |a Bioinformatics. 
650 0 |a Biochemistry. 
650 1 4 |a Life Sciences. 
650 2 4 |a Bioinformatics. 
650 2 4 |a Computational Biology/Bioinformatics. 
650 2 4 |a Biochemistry, general. 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer eBooks 
776 0 8 |i Printed edition:  |z 9781849961035 
830 0 |a Computational Biology,  |x 1568-2684 ;  |v 11 
856 4 0 |u http://dx.doi.org/10.1007/978-1-84996-104-2  |z Full Text via HEAL-Link 
912 |a ZDB-2-SCS 
950 |a Computer Science (Springer-11645)