mTOR Inhibition for Cancer Therapy: Past, Present and Future

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Mita, Monica (Επιμελητής έκδοσης), Mita, Alain (Επιμελητής έκδοσης), Rowinsky, Eric K. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Paris : Springer Paris : Imprint: Springer, 2016.
• Έκδοση: 1st ed. 2016.
• Θέματα: Medicine.; Molecular biology.; Hematology.; Oncology.; Medicine & Public Health.; Molecular Medicine.

This book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for t...

Πίνακας περιεχομένων:

• Forward
• Past
• mTOR inhibitors: a little bit of history
• Present
• The mTOR pathway
• The evolving role of mTOR inhibitors in renal cell carcinoma
• The role of mTOR inhibitors in breast cancer
• The role of mTOR inhibitors in neuroendocrine tumors
• New indications of mTOR inhibitors in rare tumors
• The role of mTOR inhibitors in the treatment of hematological malignancies
• The clinical pharmacology and toxicity profile of rapalogs
• Resistance to mTOR inhibitors
• Rational combinations of mTOR inhibitors as anticancer strategies
• Future
• Predictive biomarkers of response to mTOR inhibitors
• The potential future indication of rapamycin analogs for the treatment of other solid tumors
• mTOR inhibition beyond rapalogs
• mTOR, aging and cancer: the missing link?
• New study design for mTOR inhibitors and other biological agents
• Future directions for the development of mTOR inhibitors.